Pregled bibliografske jedinice broj: 1171843
HPMC matrix tablets swelling properties as a prediction tool for gliclazide release behavior by texture analysis
HPMC matrix tablets swelling properties as a prediction tool for gliclazide release behavior by texture analysis // Farmacevtski Vestnik 59 (Special Issue) / Mrhar, Aleš ; Baumgartner, Saša (ur.).
Ljubljana: Slovenian Pharmaceutical Society, 2008. str. 256-257 (poster, međunarodna recenzija, prošireni sažetak, znanstveni)
CROSBI ID: 1171843 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
HPMC matrix tablets swelling properties as a
prediction tool for gliclazide release behavior by
texture analysis
Autori
Dragić, Tijana ; Jelčić, Želimir ; Lusina Kregar, Maja ; Mirić, Snježana
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, prošireni sažetak, znanstveni
Izvornik
Farmacevtski Vestnik 59 (Special Issue)
/ Mrhar, Aleš ; Baumgartner, Saša - Ljubljana : Slovenian Pharmaceutical Society, 2008, 256-257
Skup
7th Central European Symposium on Pharmaceutical Technology and Biodelivery Systems
Mjesto i datum
Ljubljana, Slovenija, 18.09.2008. - 20.09.2008
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
gliclazide ; HPMC matrix ; swelling ; texture analysis ; drug release
Sažetak
The aim of this study was to monitor swelling process and gel growth by using texture analyzer and to investigate the kinetics of drug release from HPMC matrix tablets. The texture analyzer method for monitoring swelling process was proven to be sensitive to small differences in gel properties. Drug release mechanism is pH independent and was found to be a complex combination of diffusion, swelling and erosion. However, this study shows that the matrix swelling and gliclazide release is mainly achieved by diffusion process caused by the softening of the gel formed.
Izvorni jezik
Engleski
Znanstvena područja
Farmacija
POVEZANOST RADA
Ustanove:
PLIVA HRVATSKA d.o.o.
