Pregled bibliografske jedinice broj: 1170853
Randomized Clinical Trial investigating Self- Assembling Peptide P11-4 for Treatment of Early Occlusal Caries.
Randomized Clinical Trial investigating Self- Assembling Peptide P11-4 for Treatment of Early Occlusal Caries. // Scientific reports, 10 (2020), 1; 4195, 8 doi:10.1038/s41598-020-60815-8 (međunarodna recenzija, članak, znanstveni)
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Naslov
Randomized Clinical Trial investigating Self-
Assembling Peptide P11-4 for Treatment of Early
Occlusal Caries.
(Randomized Clinical Trial investigating Self-
Assembling Peptide P11-4 for Treatment of Early
Occlusal Caries)
Autori
Doberdoli, Dafina ; Bommer, Claudine ; Begzati, Agim ; Haliti, Fehim ; Heinzel-Gutenbrunner, Monika ; Jurić, Hrvoje
Izvornik
Scientific reports (2045-2322) 10
(2020), 1;
4195, 8
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
early occlusal caries ; fluorides ; self-assembling peptides
Sažetak
Non-invasive caries treatment is a major focus in modern dentistry. The present study was designed to evaluate the effectiveness of monomeric self- assembling peptide P11-4 (SAP P11-4) in combination with fluoride varnish or polymeric self-assembling peptide matrix (SAPM) in treatment of non-cavitated occlusal caries. Ninety children and adolescents were included in this randomized, gold-standard-controlled clinical trial. Test Group 1 received SAP P11-4 and twice fluoride varnish at baseline and Day 180, Test Group 2 received SAP P11-4 on baseline and twice weekly SAPM (home-application), and Control Group received fluoride varnish on baseline and Day 180. Caries progression was measured by laser fluorescence, Nyvad Caries Activity, ICDAS-II- codes, and investigator assessments. Laser fluorescence changes demonstrated superior results for Test Group 1 and 2, as values decreased compared to an increase for the Control Group (p < 0.0005). ICDAS-II codes at Day 360 showed partial regression for Test Group 1 (6.7%) and Test Group 2 (20.0%) and partial progression for Control Group (23.3%) (p < 0.01). Nyvad Caries Activity yielded superior caries inactivation for Test Groups, compared to Control Group (p = 0.002). This trial showed that SAP P11-4, applied either in combination with fluoride varnish or twice weekly SAPM, was a superior treatment for early caries compared to fluoride varnish alone.
Izvorni jezik
Engleski
Znanstvena područja
Dentalna medicina
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- Social Science Citation Index (SSCI)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
