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Pregled bibliografske jedinice broj: 1170546

Macrolide and lincosamide antibiotic exposure in the first trimester of pregnancy and risk of congenital anomaly: A European case- control study

Leke, Aminkeng Zawuo; Dolk, Helen; Loane, Maria; Casson, Karen; Nelen, Vera; Barišić, Ingeborg; Garne, Ester; Rissman, Anke; O’Mahony, Mary; Neville, Amanda J. et al.
Macrolide and lincosamide antibiotic exposure in the first trimester of pregnancy and risk of congenital anomaly: A European case- control study // Reproductive Toxicology, 100 (2021), 101-108 doi:10.1016/j.reprotox.2021.01.006 (međunarodna recenzija, članak, znanstveni)

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Naslov
Macrolide and lincosamide antibiotic exposure in the first trimester of pregnancy and risk of congenital anomaly: A European case- control study

Autori
Leke, Aminkeng Zawuo ; Dolk, Helen ; Loane, Maria ; Casson, Karen ; Nelen, Vera ; Barišić, Ingeborg ; Garne, Ester ; Rissman, Anke ; O’Mahony, Mary ; Neville, Amanda J. ; Pierini, Anna ; Bergman, Jorieke E.H. ; Klungsøyr, Kari ; Materna-Kiryluk, Anna ; Bielenska, Anna Latos ; Carbonell, Clara Cavero ; Addor, Marie-Claude ; Tucker, David

Izvornik
Reproductive Toxicology (0890-6238) 100 (2021); 101-108

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Azithromycin ; Clarithromycin ; Clindamycin ; Congenital anomaly ; Erythromycin ; First trimester ; Macrolides ; Pregnancy ; Spiramycin

Sažetak
This study investigated the risk of congenital heart defects (CHD) and other congenital anomalies (CA) associated with first trimester use of macrolide antibiotics (mainly erythromycin, spiramycin, clarithromycin and azithromycin) and lincosamides (clindamycin) using a case-malformed control design. Data included 145, 936 babies with a CA diagnosis (livebirths, stillbirths and terminations of pregnancy for CA) from 15 population-based EUROCAT registries in 13 European countries, covering 9 million births 1995- 2012. Cases were babies with CHD, anencephaly, orofacial clefts, genital and limb reduction anomalies associated with antibiotic exposure in the literature. Controls were babies with other CA or genetic conditions. Main outcomes were odds ratios adjusted (AOR) for maternal age and registry, with 95 % Confidence Intervals (95 %CI). Macrolide and lincosamide exposure was recorded for 307 and 28 cases, 72 and 4 non-genetic controls, 57 and 7 genetic controls, respectively. AOR for CHD was not significantly raised (AOR 0.94, 95 %CI: 0.70-1.26 vs non-genetic controls ; AOR 1.01, 95 %CI: 0.73-1.41 vs genetic controls), nor significantly raised for any specific macrolide. The risk of atrioventricular septal defect was significantly raised with exposure to any macrolide (AOR 2.98 ; 95 %CI: 1.48-6.01), erythromycin (AOR 3.68, 95 %CI: 1.28-10.61), and azithromycin (AOR 4.50, 95 %CI: 1.30-15.58). Erythromycin, clarithromycin, azithromycin, and clindamycin were associated with an increased risk of at least one other CA. Further research is needed on the risk of specific CA associated with macrolide and lincosamide use in the first trimester, particularly relevant for the potential use of azithromycin in the treatment of COVID-19.

Izvorni jezik
Engleski



POVEZANOST RADA

Profili:

Avatar Url Ingeborg Barišić (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Leke, Aminkeng Zawuo; Dolk, Helen; Loane, Maria; Casson, Karen; Nelen, Vera; Barišić, Ingeborg; Garne, Ester; Rissman, Anke; O’Mahony, Mary; Neville, Amanda J. et al.
Macrolide and lincosamide antibiotic exposure in the first trimester of pregnancy and risk of congenital anomaly: A European case- control study // Reproductive Toxicology, 100 (2021), 101-108 doi:10.1016/j.reprotox.2021.01.006 (međunarodna recenzija, članak, znanstveni)
Leke, A., Dolk, H., Loane, M., Casson, K., Nelen, V., Barišić, I., Garne, E., Rissman, A., O’Mahony, M. & Neville, A. (2021) Macrolide and lincosamide antibiotic exposure in the first trimester of pregnancy and risk of congenital anomaly: A European case- control study. Reproductive Toxicology, 100, 101-108 doi:10.1016/j.reprotox.2021.01.006.
@article{article, author = {Leke, Aminkeng Zawuo and Dolk, Helen and Loane, Maria and Casson, Karen and Nelen, Vera and Bari\v{s}i\'{c}, Ingeborg and Garne, Ester and Rissman, Anke and O’Mahony, Mary and Neville, Amanda J. and Pierini, Anna and Bergman, Jorieke E.H. and Klungs\oyr, Kari and Materna-Kiryluk, Anna and Bielenska, Anna Latos and Carbonell, Clara Cavero and Addor, Marie-Claude and Tucker, David}, year = {2021}, pages = {101-108}, DOI = {10.1016/j.reprotox.2021.01.006}, keywords = {Azithromycin, Clarithromycin, Clindamycin, Congenital anomaly, Erythromycin, First trimester, Macrolides, Pregnancy, Spiramycin}, journal = {Reproductive Toxicology}, doi = {10.1016/j.reprotox.2021.01.006}, volume = {100}, issn = {0890-6238}, title = {Macrolide and lincosamide antibiotic exposure in the first trimester of pregnancy and risk of congenital anomaly: A European case- control study}, keyword = {Azithromycin, Clarithromycin, Clindamycin, Congenital anomaly, Erythromycin, First trimester, Macrolides, Pregnancy, Spiramycin} }
@article{article, author = {Leke, Aminkeng Zawuo and Dolk, Helen and Loane, Maria and Casson, Karen and Nelen, Vera and Bari\v{s}i\'{c}, Ingeborg and Garne, Ester and Rissman, Anke and O’Mahony, Mary and Neville, Amanda J. and Pierini, Anna and Bergman, Jorieke E.H. and Klungs\oyr, Kari and Materna-Kiryluk, Anna and Bielenska, Anna Latos and Carbonell, Clara Cavero and Addor, Marie-Claude and Tucker, David}, year = {2021}, pages = {101-108}, DOI = {10.1016/j.reprotox.2021.01.006}, keywords = {Azithromycin, Clarithromycin, Clindamycin, Congenital anomaly, Erythromycin, First trimester, Macrolides, Pregnancy, Spiramycin}, journal = {Reproductive Toxicology}, doi = {10.1016/j.reprotox.2021.01.006}, volume = {100}, issn = {0890-6238}, title = {Macrolide and lincosamide antibiotic exposure in the first trimester of pregnancy and risk of congenital anomaly: A European case- control study}, keyword = {Azithromycin, Clarithromycin, Clindamycin, Congenital anomaly, Erythromycin, First trimester, Macrolides, Pregnancy, Spiramycin} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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