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Pregled bibliografske jedinice broj: 1170511

Bioprospecting of Less-Polar Fractions of Ericaria crinita and Ericaria amentacea: Developmental Toxicity and Antioxidant Activity

Radman, Sanja; Čižmek, Lara; Babić, Sanja; Cikoš, Ana-Marija; Čož-Rakovac, Rozelindra; Jokić, Stela; Jerković, Igor
Bioprospecting of Less-Polar Fractions of Ericaria crinita and Ericaria amentacea: Developmental Toxicity and Antioxidant Activity // Marine drugs, 20 (2022), 1; 57, 18 doi:10.3390/md20010057 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1170511 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Bioprospecting of Less-Polar Fractions of Ericaria crinita and Ericaria amentacea: Developmental Toxicity and Antioxidant Activity

Autori
Radman, Sanja ; Čižmek, Lara ; Babić, Sanja ; Cikoš, Ana-Marija ; Čož-Rakovac, Rozelindra ; Jokić, Stela ; Jerković, Igor

Izvornik
Marine drugs (1660-3397) 20 (2022), 1; 57, 18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
brown algae ; UHPLC-ESI-HRMS ; fatty acid amides ; fucoxanthin ; pheophytin a, b and their derivatives ; terpenes ; zebrafish embryotoxicity ; antioxidant activity

Sažetak
Ericaria crinita and Ericaria amentacea from the Adriatic Sea (Croatia) were investigated with respect to the presence of less-polar compounds for the first time after fractionation by solid- phase extraction (SPE). The composition of less- polar fractions of freeze-dried E. crinita (FdEc) and E. amentacea (FdEa) were analyzed by high- performance liquid chromatography–high-resolution mass spectrometry with electrospray ionization (UHPLC-ESI-HRMS). The major identified compounds were: amides of higher aliphatic acids (palmitoleamide, linoleamide, palmitamide, oleamide and erucamide) and related compounds, carotenoid (fucoxanthin), chlorophyll derivatives (pheophytin a and b and their derivatives) and higher terpenes (loliolide, isoamijiol with its oxidation product), β-stigmasterol and (3β, 6α)-14- methylergosta-8, 24(28)-diene-3, 6-diol). The toxic effects observed on the less-polar fractions obtained from Ericaria species on zebrafish Danio rerio embryos could be associated with the high abundance of all five detected amides. The antioxidant activity of the fractions was evaluated by means of five independent assays, including the reduction of the radical cation (ABTS), the oxygen radical absorbance capacity (ORAC), ferric-reducing antioxidant power (FRAP), the 2, 2-diphenyl-1-picryl-hydrazyl (DPPH) assay and the Folin–Ciocalteu method. A higher antioxidant activity of E. amentacea in comparison to that of the E. crinita fractions was found with IC50 concentrations of 0.072 and 1.177 mg/mL, respectively. The correlation between the activity and the chemical composition revealed that the synergistic effect of different compounds impacted their antioxidant response.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija, Biotehnologija



POVEZANOST RADA

Projekti:
EK-KF-KK.01.1.1.01.0002 - Bioprospecting Jadranskog mora (Jerković, Igor; Dragović-Uzelac, Verica; Šantek, Božidar; Čož-Rakovac, Rozelinda; Kraljević Pavelić, Sandra; Jokić, Stela, EK ) ( CroRIS)

Ustanove:
Kemijsko-tehnološki fakultet, Split,
Institut "Ruđer Bošković", Zagreb,
Prehrambeno-tehnološki fakultet, Osijek

Profili:

Avatar Url Igor Jerković (autor)

Avatar Url Lara Čižmek (autor)

Avatar Url Sanja Babić (autor)

Avatar Url Ana-Marija Cikoš (autor)

Avatar Url Stela Jokić (autor)

Avatar Url Rozelinda Čož-Rakovac (autor)

Avatar Url Sanja Radman (autor)

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com fulir.irb.hr doi.org

Citiraj ovu publikaciju:

Radman, Sanja; Čižmek, Lara; Babić, Sanja; Cikoš, Ana-Marija; Čož-Rakovac, Rozelindra; Jokić, Stela; Jerković, Igor
Bioprospecting of Less-Polar Fractions of Ericaria crinita and Ericaria amentacea: Developmental Toxicity and Antioxidant Activity // Marine drugs, 20 (2022), 1; 57, 18 doi:10.3390/md20010057 (međunarodna recenzija, članak, znanstveni)
Radman, S., Čižmek, L., Babić, S., Cikoš, A., Čož-Rakovac, R., Jokić, S. & Jerković, I. (2022) Bioprospecting of Less-Polar Fractions of Ericaria crinita and Ericaria amentacea: Developmental Toxicity and Antioxidant Activity. Marine drugs, 20 (1), 57, 18 doi:10.3390/md20010057.
@article{article, author = {Radman, Sanja and \v{C}i\v{z}mek, Lara and Babi\'{c}, Sanja and Ciko\v{s}, Ana-Marija and \v{C}o\v{z}-Rakovac, Rozelindra and Joki\'{c}, Stela and Jerkovi\'{c}, Igor}, year = {2022}, pages = {18}, DOI = {10.3390/md20010057}, chapter = {57}, keywords = {brown algae, UHPLC-ESI-HRMS, fatty acid amides, fucoxanthin, pheophytin a, b and their derivatives, terpenes, zebrafish embryotoxicity, antioxidant activity}, journal = {Marine drugs}, doi = {10.3390/md20010057}, volume = {20}, number = {1}, issn = {1660-3397}, title = {Bioprospecting of Less-Polar Fractions of Ericaria crinita and Ericaria amentacea: Developmental Toxicity and Antioxidant Activity}, keyword = {brown algae, UHPLC-ESI-HRMS, fatty acid amides, fucoxanthin, pheophytin a, b and their derivatives, terpenes, zebrafish embryotoxicity, antioxidant activity}, chapternumber = {57} }
@article{article, author = {Radman, Sanja and \v{C}i\v{z}mek, Lara and Babi\'{c}, Sanja and Ciko\v{s}, Ana-Marija and \v{C}o\v{z}-Rakovac, Rozelindra and Joki\'{c}, Stela and Jerkovi\'{c}, Igor}, year = {2022}, pages = {18}, DOI = {10.3390/md20010057}, chapter = {57}, keywords = {brown algae, UHPLC-ESI-HRMS, fatty acid amides, fucoxanthin, pheophytin a, b and their derivatives, terpenes, zebrafish embryotoxicity, antioxidant activity}, journal = {Marine drugs}, doi = {10.3390/md20010057}, volume = {20}, number = {1}, issn = {1660-3397}, title = {Bioprospecting of Less-Polar Fractions of Ericaria crinita and Ericaria amentacea: Developmental Toxicity and Antioxidant Activity}, keyword = {brown algae, UHPLC-ESI-HRMS, fatty acid amides, fucoxanthin, pheophytin a, b and their derivatives, terpenes, zebrafish embryotoxicity, antioxidant activity}, chapternumber = {57} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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