Naslov
Clinical Presentation in Children With Coeliac Disease in Central Europe

Autori
Riznik, Petra ; De Leo, Luigina ; Dolinsek, Jasmina ; Gyimesi, Judit ; Klemenak, Martina ; Koletzko, Berthold ; Koletzko, Sibylle ; Korponay- Szabó, Ilma Rita ; Krencnik, Tomaz ; Not, Tarcisio ; Palcevski, Goran ; Sblattero, Daniele ; Werkstetter, Katharina Julia ; Dolinsek, Jernej

Izvornik
Journal of Pediatric Gastroenterology & Nutrition (0277-2116) 72 (2021), 4; 546-551

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Adolescent ; Celiac Disease ; Child ; Child, Preschool ; Europe ; Female ; Germany ; Humans ; Italy ; Male ; Retrospective Studies ; Slovenia

Sažetak
OBJECTIVES: During the past decades, there has been a shift in the clinical presentation of coeliac disease (CD) to nonclassical, oligosymptomatic, and asymptomatic forms. We assessed clinical presentation of CD in children and adolescents in Central Europe. METHODS: Paediatric gastroenterologists in 5 countries retrospectively reported data of their patients diagnosed with CD. Clinical presentation was analyzed and the differences among very young (<3 years) and older children and adolescents were studied. RESULTS: Data from 653 children and adolescents (median age 7 years 2 months ; 63.9% girls) from Croatia, Germany, Hungary, Italy, and Slovenia were available for the analysis. One fifth (N = 134) of all children were asymptomatic. In symptomatic children, the most common leading symptom was abdominal pain (33.3%), followed by growth retardation (13.7%) and diarrhoea (13.3%). The majority of symptomatic children (47.6% ; N = 247) were polysymptomatic. Abdominal pain was the most common symptom in polysymptomatic (66.4%) as well as in monosymptomatic children (29.7%). Comparing clinical presentation of CD in very young children (younger than 3 years) with older children (3 years or older), we found that symptoms and signs of malabsorption were significantly more common in younger (P < 0.001), whereas abdominal pain and asymptomatic presentation were more common in older children and adolescents (both P < 0.001). CONCLUSION: In children with CD, abdominal pain has become the most common symptom. However, in younger children, symptoms of malabsorption are still seen frequently. This raises a question about the underlying mechanism of observed change in clinical presentation in favour of nonclassical presentation and asymptomatic disease at certain age. Copyright © 2020 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA