Naslov
Synthesis and antitumor evaluation of some new substituted amidino-benzimidazolyl-furyl-phenyl-acrylates and naphtho[2,1-b]furan-carboxylates

Autori
Hranjec, Marijana ; Grdiša, Mira ; Pavelić, Krešimir ; Boykin, David W. ; Karminski-Zamola, Grace

Izvornik
Il Farmaco (Pavia) (0014-827X) 58 (2003), 12; 1319-1324

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
synthesis ; antitumor activiti ; substituted amidino-benzimidazolyl-furyl-phenyl-acrylates ; naphtho[2 ; 1-b]furan-carboxylates

Sažetak
The multistep synthesis of a series of substituted amidino-benzimidazolyl-furyl-phenyl-acrylic acid`s esters and substituted amidino-benzimidazolyl-naphtho[2, 1-b]furan-carboxylic acid`s esters is described starting from corresponding 3-(2-furyl)-2-phenyl-acrylic acids. The new compounds were tested on the cytostatic activities against malignant cell lines: pancreatic carcinoma (MiaPaCa2), breast carcinoma (MCF7), cervical carcinoma (HeLa), laryngeal carcinoma (Hep2), colon carcinoma (HT 29), melanoma (HBL), and human fibroblast cell lines (WI-38). All compounds inhibited the proliferation of tumor cell lines. Inhibitory effect of examined compounds depended on cencentration, but without significant diference among the type of tumor cells. The compounds 2 and 5 exerted very low inhibitory effect on the growth of human fibroblasts.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA