Naslov
Synthesis, Structural Characterization and Antitumor Evaluation of Novel 1,2,3-triazole Derivatives of Benzoxazole

Autori
Ostrički, Robert ; Persoon, Leentje ; Vanstreels, Els ; Daelemans, Dirk ; Gazivoda Kraljević, Tatjana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts, 27th CROATIAN MEETING OF CHEMISTS AND CHEMICAL ENGINEERS / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna - Zagreb : Hrvatsko kemijsko društvo, 2021, 166-166

Skup
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI)

Mjesto i datum
Veli Lošinj, Hrvatska, 05.10.2021. - 08.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
benzoxazole, click reaction, antitumor evaluations

Sažetak
Cancer is the result of unwanted transformations of normal cells into tumor cells that can spread uncontrollably. It is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020. The most common types of cancer in 2020. were: breast (2, 26 million cases), lung (2, 21 million cases), colon (1, 93 million cases) and prostate cancer (1, 41 million cases). Because of its frequency and high mortality rate, there is an increased demand to develop new, potent antitumor agents. Benzoxazoles represent an important class of heterocyclic compounds that exhibit a variety of pharmacological activities such as anticancer, antibacterial, antiviral, antifungal, anti-inflammatory and more. [1-3] In order to evaluate their antitumor activity, novel benzoxazole derivatives with 1, 2, 3-triazole ring as a linker were prepared by conventional and green synthetic methods. Bezoxazole derivative linked with coumarin ring through 1, 2, 3-triazole showed the most potent activity against acute lymphoblastic leukemia (DND-41, IC50= 1 μM). [1] C. P. Kaushik, M. Chahal, .J. Chem. Sci, . 2020, 132:142 [2] U. Kamal, N. M. Javed, K. Arun, Asian J. Pharm. Clin. Res., 2020, 13, 1-14 [3] R. Sattar, R. Mukhtar, M. Atif, M. Hasnain, A. Irfan, J. Het. Chem., 2020, 57, 2079-2107

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA