Naslov
Bacterial contamination of platelet concentrates

Autori
Golubić Ćepulić, Branka ; Bojanić, Ines ; Plenković, Fini ; Lukić, Marija ; Skodlar, Jasna ; Ivanković, Zdravko ; Kalinić, Smilja

Izvornik
Infusionstherapie und transfusionsmedizin (1019-8466) 24 (1997), 4; 216-216

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
platelet concentrates ; bacterial contamination

Sažetak
Background and study design: The overall incidence of platelet transfusion-related sepsis is probably under-reported although the number of reported platelet-associated cases has increased. To determine the risk of bacterial contamination of platelet concentrates febrile transfusion reactions were monitored between 1990-1995. Units involved in reactions and patients blood were evaluated by culture tests. Results: During 6 years 245 febrile reactions were noted in 21, 869 platelet transfusions. In 24 (10%) of these reactions bacterial contamination of the platelet bag has been found. All patients receiving contaminated platelet concentrates had bone marrow failure with total neutrophil count < 0.5 × 109/L. At the time of the transfusion, 20 patients received antibiotics. Clinically, leading symptoms were rigor (74.3%), fever (62.9%) and chills (60.0%). Bacterial species most commonly found in platelet cultures were Staphyloccocus species, coagulase negative (14) and Enterococcus (4). Blood cultures have been examined in 18 patients receiving contaminated platelets. In the blood of 9 patients the same bacteria have been isolated, while in 9 patients blood cultures remained sterile. Comment and conclusion: Patients requiring platelet transfusions often have febrile reactions or they are febrile independently of platelet transfusion which is the reason for ignoring some of these reactions. Further, such patients are commonly treated with antibiotics which may minimize the clinical consequences and mask the transfusion related sepsis. Due to the high incidence of contamination (0.018), transfusions of all platelet concentrates causing febrile reactions should be discontinued and evaluated for possible bacterial contamination.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA