Naslov
Pregnancy After Simultaneous Pancreas-Kidney Transplantation in Tretman of End-Stage Diabetes Mellitus

Autori
Stanić, Žana ; Vulić, Marko ; Hrgović, Zlatko ; Fureš, Rajko ; Plazibat, Milvija ; Čečuk, Esma ; Vusić, Iva ; Lagančić, Marko

Izvornik
Zeitschrift für Geburtshilfe und Neonatologie (0948-2393) 226 (2021), 2; 86-91

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
pregnancy ; HLA ; kidney transplantation ; diabetes mellitus

Sažetak
The majority of patients with simultaneous pancreas and kid- ney transplant (SPKT) required transplantation owing to a long-standing history of insulin-dependent diabetes mellitus (IDDM). The disease causes multiple organ damage, impairs fertility, and affects quality of life. A successful kidney and pan- creas transplant can improve health, ameliorate the conse- quences of pre-existent diabetes, and restore fertility. Good graft function, without any sign of rejection, and stable doses of immunosuppressant drugs are of utmost importance prior to the planned pregnancy. SPKT recipients who become preg- nant may be at an increased risk for an adverse outcome and require meticulous multidisciplinary surveillance. We present experiences with SPKT pregnancies, traditional approaches, and recent considerations. In light of complex interactions be- tween new anatomic relations and the impact of developing pregnancy and immunosuppressive medications, special stress is put on the risk of graft rejection, development of pregnancy complications, and potential harmful effects on fetal develop- ment. Recent recommendations in management of SPKT re- cipients who wish to commence pregnancy are presented as well. Key words: transplantation, pregnancy, pancreas, kidney, simultaneous pancreas and kidney transplantation (SPKT)

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA