Naslov
Antioxidant potential of selected phenolic acids – a theoretical approach

Autori
Bumba, Valentina ; Amić, Ana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Sciforum 7th International Electronic Conference on Medicinal Chemistry - session Round table on predictive tools / - , 2021

Skup
7th International Electronic Conference on Medicinal Chemistry (ECMC 2021)

Mjesto i datum
Online, 01.11.2021. - 30.11.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
antioxidants ; cancer ; cardiovascular diseases ; computational chemistry ; neurodegenerative diseases ; phenolic acids

Sažetak
In the last several decades, antioxidants have become frequent subject of scientific investigations due to their role in oxidative stress and aetiology of various diseases. Antioxidants include a broad spectrum of mono- and polyphenolic compounds, such as phenolic acids, and also a significant number of synthetic polyphenolic compounds. In this work, an overview of theoretical research on antioxidant potential of selected phenolic acids was given. Adequate thermodynamic parameters which play the key role in selected mechanisms of antioxidant activity were also studied and a conclusion regarding antioxidant potential was drawn from this study. Additionally, results of studies of reactions of phenolic acids with free radicals were presented, and studied mechanisms were HAT, SET-PT, SPLET and RAF, in polar and non-polar medium. Based on the results of computed parameters, possible and competitive mechanisms were determined, as well as phenolic acids with higher antioxidant potential. This activity plays an important role in fighting against various chronic and age-related diseases, such as cardiovascular, neurodegenerative and some types of cancer.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA