Naslov
Transient pseudohypoaldosteronism secondary to urinary tract infection in a male infant with unilateral hydronephrosis due to primary obstructive megaureter: case report

Autori
Crnković Ćuk, Matea ; Kovačević, Ana ; Žaja, Orjena ; Požgaj-Šepec, Marija ; Roić, Goran ; Valent Morić, Bernardica ; Trutin, Ivana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Pediatric Nephrology vol.36 br.10 / - , 2021

Skup
53rd Annual Scientific Meeting of ESPN

Mjesto i datum
Amsterdam, Nizozemska, 16.09.2021. - 19.09.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
pseudohypoaldosteronism ; infant ; obstructive anomaly ; cystopyelonephritis

Sažetak
We present a case of the transient form of type 1 pseudohypoaldosteronism (S-PHA) in a 1, 5-month- old male infant who presented with lethargy, failure to thrive, severe hyponatremia (Na=118 mmol/L), hypochloremia (Cl=93 mmol/L), and fever due to urinary tract infection. Material and methods: Potassium levels were normal. Markedly elevated serum aldosterone level and elevated serum renin confirmed the diagnosis of pseudohypoaldosteronism. Renal ultrasound showed grade III hydronephrosis on the left kidney while contrast-enhanced voiding urosonography excluded the existence of vesicoureteral reflux which raised suspicion of obstructive uropathy on the level of vesicoureteral junction. Results: Serum sodium normalized after several days of intravenous fluids and antibiotic therapy after which oral supplementation of sodium was introduced. Levels of 17-hydroxyprogesterone, ACTH, cortisol, and TSH were normal. Functional MR urography conducted at the age of 3 months confirmed the diagnosis of primary congenital obstructive megaureter and the infant was referred to a pediatric surgeon. Conclusions: Although a rare occurrence, S-PHA can be a potentially life- threatening condition in infants if not recognized and treated adequately. Therefore, serum concentrations of electrolytes should be obtained in every child with a diagnosed obstructive anomaly of the urinary tract and/or acute cystopyelonephritis. On the other hand, every child with diagnosed S-PHA should be evaluated for the obstructive anomaly of the urinary tract.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA