Naslov
Structures of Two Novel penam Derivatives

Autori
Danilovski, Aleksandar ; Vinković, Mladen ; Herak Jure

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
Fifth Slovenian-Croatian Crystallographic Meeting

Mjesto i datum
Zreče, Slovenija, 1996

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
penam ; optically active ; x-ray crystallography ; conformation

Sažetak
The X-ray structure analysis of both optically active penam derivatives (2S, 4S, 5R, 6S)-2-benzylcarbamoyl-6-bromo-3, 3-dimethyl-7-oxo-4-thia-1- azabicyclo[3.2.0]heptane-4-oxide, C~15~H~17~BrN~2~O~3~S.H~2~O (I), and (5R)-3-benzylimino-2-isopropylidene-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane, C~15~H~16~N~2~OS (II), have been determined in order to ascertain their absolute configuration. Both compounds adopted open-book conformation of fused beta-lactam and thiazolidine ring. The beta-lactam ring is in a distorted planar conformation while the thiazolidine ring is in an envelope conformation. Pyramidalisation effect of the N1 atom in both compounds has been characterised by nitrogen shift from the plane of its substituents of 0.344(5) and 0.350(5) %A in molecules A and B in compound (I), as well as of 0.410(5) %A in compound (II).

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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