Pregled bibliografske jedinice broj: 1164844
Functional derivatives of 4-oxoazetidine-2-sulfinic acids in asymmetric synthesis of 2-azacepham sulfoxides and their transformation
Functional derivatives of 4-oxoazetidine-2-sulfinic acids in asymmetric synthesis of 2-azacepham sulfoxides and their transformation // Tetrahedron, 51 (1995), 17; 5083-5092 doi:10.1016/0040-4020(95)98705-M (međunarodna recenzija, članak, znanstveni)
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Naslov
Functional derivatives of 4-oxoazetidine-2-sulfinic acids in asymmetric synthesis of 2-azacepham sulfoxides and their transformation
Autori
Herak, Jure ; Vinković, Mladen ; Lukić, Irena
Izvornik
Tetrahedron (0040-4020) 51
(1995), 17;
5083-5092
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
asymmetric synthesis ; 4-oxoazetidine-2-sulfinic acids ; cyclization
Sažetak
The enantiomerically pure 2-azacepham sulfoxide 2a was synthesized by stereocontrolled intramolecular cyclization of sulfinates 3 or sulfinamides 8 in the presence of dry hydrogen chloride followed by triethylamine. The cyclization accrued via equilibrated mixtures of sulfinyl chlorides, which presence was confirmed by chemical transformations. The absolute configuration of the sulfinic acid 9a as a product of their hydrolysis was determinate by a single crystal X-ray analysis. Synthesis and ring opening of substituted 2-azacephams via equilibrated mixtures of sulfinyl chlorides were performed
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Ustanove:
Pliva-Istraživački institut
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
