Naslov
Tip of the iceberg: Immunohistochemical markers reveal malignant transformation underneath a vocal polyp surface

Autori
Braut, Tamara ; Krstulja, Mira ; Marijić, Blažen ; Maržić, Diana ; Kujundžić, Milodar ; Zamolo, Gordana ; Vučinić, Damir ; Oštarijaš, Eduard

Izvornik
Medicina Fluminensis (1847-6864) 57 (2021), 2; 171-176

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
epithelial atypia ; immunohistochemistry ; laryngeal polyps ; molecular markers ; squamous cell carcinoma

Sažetak
Novel molecular techniques including markers of laryngeal carcinogenesis could improve the difficult diagnosis of a wide array of laryngeal polypoid changes. The case reported herein shows that not every clinically diagnosed vocal fold polyp is a benign lesion as mostly considered in the literature. Further assessment including carcinogenesis markers detected a nest of micro- invasive squamous cell carcinoma. Therefore, we recommend biopsy backed up with immunohistochemical analysis whenever there is a suspicious polypoid formation in order to exclude or confirm a malignant transformation because of the possibility of multi-focal growth in the active laryngeal epithelium.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA