Naslov
Transient boundaries and compartments of developing human fetal striatum: the role of lecticans and tenascins.

Autori
Darmopil, Sanja ; Bobić-Rasonja, Mihaela ; Milković-Periša, Marija ; Radošević, Velena ; Jovanov-Milošević, Nataša

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Clinical neuropathology, 40 (2021), Suppl 1 / - , 2021, S34-S35

Skup
12th European congress of neuropathology

Mjesto i datum
Online, 31.05.2021. - 03.06.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ECM ; human fetal striatum ; tenascin ; neurocan ; versican

Sažetak
Introduction: The exact relationship between the fetal and adult compartmental layout of the striatum, as well as the molecular mechanisms that rely under it, are still a matter of inconclusive debate, especially in human brain. Previous animal studies demonstrated that future striosome and matrix neurons show distinct adherent properties, could still segregate in the absence of dopamine afferents and that their early destruction does not affect early compartmental distribution of the dopaminergic innervation in the striatum. These findings suggest that the cell surface and extracellular matrix (ECM) molecules play a significant role in the formation of striatal compartments. Methods: In this study, we evaluated the expression patterns of neurocan, versican V0/1, and neurocan binding glycoprotein tenascin C in postmortal human brain from 10th postconceptional weeks (PCW) to the 3rd postnatal months. Results and conclusion: We observed early, homogenous ex- 12th European Congress of Neuropathology, May 31 – June 3, 2021 S35 pression of these ECM components in human fetal striatum at 11th PCW that gradually increases in complexity and begins to show clear compartimental organization at 16th PCW. Both lecticans expression ceases around 25th PCW, while the tenascin is present until 3rd postnatal month in the caudate nucleus. In midgestation period (18th – 24th PCW), all studied ECM components show prominent expression in the perimeters, a tight cell-free zone that surrounds the cell islands. Finally, the observed expression profile of the ECM components correlates well with the sequence of growth and maturation of striatal afferents, and indicates their involvement in the formation of boundaries between striatal modules

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA