Naslov
Semiquantitative analysis of salivary scan time- activity curves in patients with Sjögren's syndrome

Autori
Kustić, D ; Vukšić, J

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Skup
Tenth International Congress of the Croatian Society of Nuclear Medicine

Mjesto i datum
Vodice, Hrvatska, 03.09.2021. - 05.09.2021

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Time-activity curves ; Sjögren's syndrome ; salivary scan

Sažetak
Aim: To compare the ability of eight objective semiquantitative indices from salivary scan time- activity curves (TACs) to predict Sjögren's syndrome (SS). Methods: Patients with confirmed SS referred to the General Hospital of Šibenik for salivary gland scintigraphy between 2018 and 2021 were retrospectively enrolled and assigned to the SS group. Those whose diagnostic tests, including scintigraphy, indicated normal salivary function were assigned to the control group. Exclusion criteria were: history of head/neck radiation, lymphoma, sarcoidosis, HCV, HIV infection, hyperparathyroidism. Anterior head and neck 20-min dynamic imaging started at intravenous injection of 250 MBq of 99m Tc-pertechnetate in the supine position, with a GE camera, 5 seconds / frame, matrix 128x128. Salivary secretion was stimulated with lemon juice per os, 10 minutes post injection, avoiding patient's head movements. For the purpose of this study, images acquired earlier were retrieved and reanalyzed. Regions of interest (ROIs) were plotted manually on parotid (PGs) and submandibular glands (SGs) on both sides, with a rectangular background (Bg) ROI drawn in the right frontal region. After Bg subtraction, PG and SG TACs were generated. On each, eight indices were assessed and tested by univariate and multivariate logistic regression for binary outcomes (SS yes/no), revealing those associated with SS at p<0.05. A graphical illustration of the eight indices on a TAC will be presented. Results: Out of a total of 108 participants, 104 females and 4 males, 86 were assigned to the SS group and 22 to the control group. The median age was 45 (22-64) years. No differences were observed between the left and the right side for both PGs and SGs represented by any of the indices assessed (t- test). Mean values from the two sides, calculated for TAC indices in the control group vs SS group were, as follows: (1) vascular perfusion peak (kcount) 22.01 vs 20.89 (PG), 19.79 vs 19.11 (SG) ; (2) uptake rate (cps/s) 0.372 vs 0.149 (PG), 0.261 vs 0.134 (SG) ; (3) excretion fraction (%) 64.224 vs 34.182 (PG), 52.444 vs 31.102 (SG) ; (4) time at maximum accumulation (min) 4.9 vs 5.2 (PG), 4.8 vs 5.1 (SG) ; (5) maximum accumulation (%) 64.66 vs 51.68 (PG), 45.22 vs 33.33 (SG) ; (6) secretion velocity (%/s) 2.41 vs 1.28 (PG), 1.31 vs 1.11 (SG) ; (7) time from stimulation to minimum gland activity (s) 35.2 vs 47.0 (PG), 38.3 vs 44.1 (SG) ; (8) the same-side PG to SG ratio 1.425 vs 1.112. Of the eight indices, PG uptake rate, PG excretion fraction, and PG to SG ratio retained significant associations with SS. Conclusion: PGs are those that are predominantly affected by functional impairment in SS. TAC-derived semiquantitative indices improve the accuracy of salivary gland scintigraphy in diagnosing SS.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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