Naslov
Randomized Trial of Azithromycin in the Prophylaxis of Mediterranean Spotted Fever

Autori
Dželalija, Boris ; Petrovec, Miro ; Avšič-Županc, Tatjana ; Strugar, Jadranka ; Anić Milić, Tatjana

Izvornik
Acta Medica Croatica (1330-0164) 56 (2002), 2; 45-47

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
azithromycin; Croatia; Mediterranean spotted fever; prophylaxis; ticks

Sažetak
A randomized clinical trial was undertaken to compare clinical and serologic parameters of the efficacy of one-dose azithromycin in the prophylaxis of Mediterranean spotted fever (MSF)in 122 persons with a tick bite history. Antibodies to R. conorii were detected by indirect immunofluorescence assay in 55 (45.1%)of 122 subjects. Positive result was obtained in 19 (31.1%) of 61 subjects with azithromycin prophylaxis and in 36 (59.0%) of 61 subjects without prophylaxis. In subjects with prophylaxis clinical signs of the disease were not recorded at all, whereas asymptomatic infection was detected in 19(31.1%) of 61 subjects. Based on the results obtained in our study, we assume that a single dose of azithromycin is promising in MSF prevention.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA