Naslov
Inbreeding and Risk of Complex Chronic Diseases

Autori
Rudan, Igor ; Rudan, Diana ; Janićijević, Branka ; Smolej-Narančić, Nina ; Campbell, Harry ; Carothers, Andrew ; Wright, Alan ; Rudan, Pavao

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Inter-Congress of IUAES 2002, The Human Body in Anthropological Perspectives (Abstracts) / Omoto, Keiichi - Tokyo : The Anthropological Society of Nippon, 2002, 87-87

Skup
Inter-Congress of IUAES 2002, The Human Body in Anthropological Perspectives

Mjesto i datum
Tokyo, Japan, 22.09.2002. - 27.09.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
inbreeding ; complex diseases ; postreproductive age

Sažetak
New molecular insights provided plausible scenarios for importance of inbreeding in mediating susceptibility to complex chronic diseases. Still, hardly anything is known of the risks of inbreeding in postreproductive age. This study investigated the relationship between inbreeding and prevalence of 10 complex chronic diseases (coronary disease, stroke, cancer, two common psychiatric disorders, asthma, diabetes, gout, peptic ulcer and epilepsy) in 14 isolate villages on 3 neighboring islands in Croatia. These populations are unique as specific historic circumstances led some to favor and other to avoid inbreeding while sharing similar environment and lifestyle. Variation in education, occupation, diet, smoking and obesity was characterized and inbreeding coefficient (F) of each village computed in adult population based on 3 different methods. Prevalence of diseases was determined through a review of medical records by two trained physicians and a local GP in six villages with the greatest F (N=1, 401), four with intermediate F (N=998) and four with lowest F (N=1, 501). After standardizing the rates by sex and age, it has been shown that inbreeding could be responsible for observed non-specific increase in prevalence of all studied diseases except stroke and adult-type diabetes, showing dose-response effect and the relative risks ranging between 1.2 and 8.8 per 5% of inbreeding. Subsequent cohort and case-control study at the level of individual examines provided further insights into genetic architecture of complex chronic diseases.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Etnologija i antropologija

POVEZANOST RADA