Naslov
AMIDINO-SUBSTITUTED BENZAZOLES: PROMISING ANTITRYPANOSOMAL AND CYTOSTATIC AGENTS

Autori
Rep, Valentina ; Raić-Malić, Silvana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Skup
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI)

Mjesto i datum
Veli Lošinj, Hrvatska, 05.10.2021. - 08.10.2021

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
amidino derivatives ; benzimidazole ; benzothiazole ; antitrypanosomal activity ; anticancer activity

Sažetak
Cancer, an uncontrolled, rapid and pathological proliferation of cells, is the second leading cause of death, with more than 18 million cases worldwide annually. On the other hand, human African trypanosomiasis (HAT) is a life- threatening, neglected tropical disease, with around 60 million people at risk in 36 sub-Saharan African countries. The current drugs used to treat HAT, are toxic and not always effective due to the appearance of drug-resistance.[1, 2] In continuation of our scientific research based on the development of aromatic amidines as DNA- binding ligands, cytostatic and antitrypanosomal agents [2–5], we have designed and synthesized novel amidino-substituted benzazole derivatives. Design of novel amidino derivatives was focused on diversification of three regions of target molecules: type of amidino substituent on left- hand side and type of aromatic and aliphatic substituents on right-hand side of a molecule, as well as central heterocycle from benzimidazole to benzothiazole to modulate biological properties.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA