Naslov
Antibiotic prophylaxis for premature rupture of membranes and perinatal outcome

Autori
Barišić, Tatjana ; Mandić, Vjekoslav ; Tomić, Vajdana ; Pupić-Bakrač, Ana ; Novaković, Gorjana

Izvornik
The Journal of Maternal-Fetal & Neonatal Medicine (1476-7058) 30 (2016), 5; 580-584

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
Antibiotic prophylaxis ; perinatal outcomes ; premature rupture of membranes

Sažetak
Aim: To evaluate the perinatal outcomes of newborns after premature rupture of membranes (PROM) at the term according to the timing of initial antibiotic administration. Material and methods: This is a retrospective, cohort study investigating perinatal outcomes of newborns in pregnant women with PROM at the term who were treated with ampicillin within or after 6 h from the PROM. Statistical analysis was performed using Student's t-test for continuous variables test and chi-square or for categorical data. Results: The study involved 144 pregnant women with PROM and their newborns, a lower number received antibiotics after birth were in the group who received antibiotics within 6 h of PROM (26.4% versus 73.6%), the mediane values of C-reactive protein were lower (3.0 ± 2.9 mg/l versus 6.1 ± 7.3 mg/l ; p < 0.001), their newborns remained shorter in hospital after birth (4.13 versus 4.94 ; p =0.023) and time between PROM and delivery was shorter (p < 0.001). In group who received prophylactic antibiotics after 6 h of the PROM had significantly higher frequency of infection in newborns (45.3% versus 15.4%), and higher number of chorioamnionitis (9.72% versus 3, 47%) compared to group who received antibiotics within 6h. Conclusion: Timely usage of antibiotic prophylaxis and shorter time between PROM and delivery improve perinatal outcomes.

Izvorni jezik
Engleski

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