Naslov
Early predictors of severity and mortality in COVID-19 hospitalized patients

Autori
Mustafić, Sehveta ; Jusufović, Edin ; Hukić, Fatima ; Trnačević, Emir ; Divković, Anja ; Trnačević, Alma

Izvornik
Medicinski glasnik Ljekarske komore Zeničko-dobojskog kantona (1840-0132) 18 (2021), 2; 384-393

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ferritin ; LDH ; O2 saturation ; SARS-CoV-2

Sažetak
Aim To identify laboratory tests for early detection and the development of more severe illness and death in COVID-19 hospitalized patients. Methods A prospective study was done on 66 hospitalized COVID- 19 patients (males: 54.5% ; mean age 70.1 ± 9.6 years) who were stratified into: moderate (n=36 ; 54.5%), severe (n=12 ; 18.2%), and critically ill (n=18 ; 27.3%). Besides clinical findings, a wide spectrum of laboratory parameters was monitored at admission and control during the first seven days of hospitalization and used to predict progression from non-severe to severe illness and to predict the final outcome. Results Critically ill patients showed a higher control value of white blood cell count, C- reactive protein, lactate dehydrogenase, ferritin, but lower lymphocyte count and O2 saturation. Patients with fatal outcome (23 ; 34.85%) showed a higher control value of neutrophil, lactate dehydrogenase, ferritin, and lower lymphocyte and O2 saturation. Progression from moderate to severe or critical illness was predicted by increasing lactate dehydrogenase (95% CI 0.5803 to 0.8397 ; p=0.003729), increase in ferritin (95% CI 0.5288 to 0.8221 ; p=0.03248), and by drop in O2 saturation (95% CI 0.5498 to 0.8179 ; p=0.01168). A fatal outcome was predicted by increase in ferritin (95% CI 0.5059 to 0.8195 ; p=0.04985), as well as by drop in O2 saturation (95% CI 0.5916 to 0.8803 ; p=0.001861). Conclusion Increase in ferritin, and drop in O2 saturation could be the most important prognostic parameters for the development of more severe clinical illness and death in COVID- 19 hospitalized patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA