Naslov
The Association of Subclinical Insulin Resistance with Thyroid Autoimmunity in Euthyroid Individuals.

Autori
Blaslov, Kristina ; Gajski, Domagoj ; Vucelić, Vesna ; Gaćina, Petar ; Mirošević, Gorana ; Marinković, Jelena ; Vrkljan, Milan ; Rotim, Krešimir

Izvornik
Acta clinica Croatica (0353-9466) 59 (2020), 4; 696-702

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
5-hour oral glucose tolerance test ; Hashimoto thyroiditis ; Insulin resistance.

Sažetak
Hashimoto thyroiditis is characterized by anti- thyroid peroxidase (anti-TPO) and anti- thyroglobulin (anti-Tg) antibodies that gradually lead to thyroid cell destruction. As hypothyroidism has been associated with insulin resistance (IR), we aimed to investigate whether IR is associated with thyroid antibody presence and whether the degree of IR correlates with their concentration in euthyroid individuals. A total of 164 non-diabetic, euthyroid individuals, average age 34 years, were included in the study, divided into two groups according to Hashimoto thyroiditis and underwent 5-hour oral glucose tolerance test. The degree of IR was evaluated by the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). The Hashimoto thyroiditis group had higher HOMA-IR (p=0.003) and lower glucose levels (p=0.04). HOMA- IR correlated positively with anti-TPO (p<0.001). Linear logistic regression revealed that anti-TPO concentration increased by 18.13 (p=0.001) with each HOMA-IR unit. IR might trigger thyroid antibody production and Hashimoto thyroiditis development, which needs to be evaluated in further larger scale follow up studies.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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