Naslov
Antibody clone-dependent thyroid transcription factor-1 expression in a primary breast carcinoma

Autori
Korsa, Lea ; Lukac, Ana ; Kovacevic, Lucija ; Prutki, Maja ; Marusic, Zlatko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
“Abstracts : 32 nd Congress of the ESP and XXXIII International Congress of the IAP.” Virchows Archiv : an international journal of pathology vol. 477, Suppl 1 (2020): 1-390. doi:10.1007/s00428-020- 02938-x / - , 2020, 1-1

Skup
32ndCongress of the ESP and XXXIII International Congress of the IAP

Mjesto i datum
Glasgow, Ujedinjeno Kraljevstvo, 05.12.2020. - 09.12.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Thyroid Transcription Factor-1

Sažetak
Background & objectives: Thyroid Transcription Factor-1 (TTF-1) can be a useful marker for lung and thyroid primaries. However, TTF-1 expression has been reported in up to 2.5% of breast carcinomas. There are two main commercially available TTF-1 antibody clones: 8G7G3/1 and SPT24. Methods: A 60-year-old woman presented with a large tumour involving the entire right breast together with multiple pulmonary and mediastinal tumour masses. Due to the aggressive course, the working diagnosis was a lung primary producing breast metastasis. Breast and lung core needle biopsies both revealed a TTF-1, ER and GATA3 positive adenocarcinoma, while napsin A, PR and HER2 were negative. Results: Endocrine therapy was administered, leading to significant reduction in the size and number of pulmonary and mediastinal metastases. Two years later, a sanitary mastectomy was performed. The breast tumour was positive for ER and GATA3, and negative for napsin A and PR. This time, TTF-1 was performed with both commercially available clones, showing a positive reaction with SPT24 and a negative reaction using the 8G7G3/1 clone. Conclusion: Breast metastases from extramammary malignancies are rare (0.2-2% of all tumours), with lung being one of the most frequent primary sites. TTF-1 clone selection can have clinical significance in the workup of a potential metastatic lung adenocarcinoma, especially in settings with limited amount of tumour tissue. In the setting of breast vs lung primary, an antibody panel including napsin A and GATA3 should be used, as occasional ER- positive lung carcinomas as well as TTF-1 positive breast carcinomas have been documented.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA