Naslov
NMR methods for studying structure and interactions of macrozones

Autori
Mikulandra, Ivana ; Jednačak, Tomislav ; Habinovec, Iva ; Novak, Predrag

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Adriatic NMR Conference 2021 : Book of abstracts / Bregović, Nikola ; Namjesnik, Danijel ; Novak, Predrag ; Parlov Vuković, Jelena - Zagreb : Hrvatsko kemijsko društvo, 2021, 35-35

Skup
The Adriatic NMR Conference 2021

Mjesto i datum
Primošten, Hrvatska, 13.09.2021. - 15.09.2021

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
azithromycin, biological activity, resistance, macrozones, spectroscopy NMR

Sažetak
Macrozones are novel, bioactive macrolide derivatives, conjugates of azithromycin and thiosemicarbazone. Macrolides, such as azithromycin are group of antibiotics which are active against Gram positive and some Gram negative bacteria. They exert their biological activity by binding to the 50S ribosome subunit. Due to the frequent and improper use of drugs bacterial resistance has emerged. There is a need to discover new, more effective antibiotics. In this work, three classes of macrozones were synthesized and characterized by NMR spectroscopy. In order to investigate mechanisms of macrozones activity, interactions with E. Coli ribosome were studied by trNOESY and STD NMR methods. Since 3D structure plays a significant role in bioactivity, free and bound state conformations of macrozones were also investigated. These results should contribute to discover and design new compounds with improved antibacterial activity.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA