Naslov
Insulin resistance as a common link between current Alzheimer’s disease hypotheses

Autori
Santos Alves, Suélen ; da Silva-Junior, Rui Milton Patrício ; Servilha-Menezes, Gabriel ; Homolak, Jan ; Šalković-Petrišić, Melita ; Garcia-Cairasco, Norberto

Izvornik
Journal of alzheimers disease (1387-2877) 82 (2021), 1; 71-105

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Alzheimer’s disease ; biomarkers ; insulin resistance ; memory ; metabolism

Sažetak
Abstract: Almost 115 years ago, Alois Alzheimer described Alzheimer’s disease (AD) for the first time. Since then, many hypotheses have been proposed. However, AD remains a severe health public problem. The current medical approaches for AD are limited to symptomatic interventions and the complexity of this disease has led to a failure rate of approximately 99.6%in AD clinical trials. In fact, no new drug has been approved for AD treatment since 2003. These failures indicate that we are failing in mimicking this disease in experimental models. Although most studies have focused on the amyloid cascade hypothesis of AD, the literature has made clear that AD is rather a multifactorial disorder. Therefore, the persistence in a single theory has resulted in lost opportunities. In this review, we aim to present the striking points of the long scientific path followed since the description of the first AD case and the main AD hypotheses discussed over the last decades. We also propose insulin resistance as a common link between many other hypotheses.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA