Naslov
Oral beta-lactam challenge test without antecedent skin testing in children with history of allergy to beta-lactam

Autori
Štefanović Mihatov, Iva ; Vrsalović, Renata ; Marković Perić, Gabrijela

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Archives of Disease in Childhood / Brown, Nick - , 2021, 70-70

Skup
10th Congress of European Paediatric Association EPA/UNEPSA jointly held with 14 th Congress of Croatian Paediatric Society

Mjesto i datum
Zagreb, Hrvatska, 07.10.2021. - 09.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
beta lactam ; allergy ; oral provocation test

Sažetak
Direct oral challenge was performed in patients with history of benign rash associated with beta- lactam antibiotic. Because detailed description of suspected allergic reaction could not be provided from all caregivers, all patients went specific IgE to amoxicillin and/or basophil degranulation test to culprit drug which was negative. 19 patients were included, average age 6 years and 1 month. In 17 patients suspected allergic reaction was caused by amoxicillin (AMX) ; 8 of which in combination with clavulanic acid, one with phenoxymethylpenicillin and one with cephalexin. A DPT involved open 3-step graded oral provocation test with AMX, time interval between the doses was 2h. The patients were monitored for 24h after challenge and were discharged with instructions to call in the event of a delayed reaction. After DPT there was no reaction in 89% of patients, one patient developed benign rash and one drug-induced enterocolitis syndrome.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA