Naslov
ESR Study of the Reaction Sites in the Barbituric Acid Derivatives

Autori
Herak, Janko N. ; Herak, Jure J.

Izvornik
Croatica chemica acta (0011-1643) 44 (1972), 4; 427-434

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Barbituric Acid ; ESR Study

Sažetak
ESR spectroscopy has been used to analyse free radicals in the barbituric acid derivatives exposed to thermal H atoms or to excited Ar atoms. Reaction with both types of atoms leads to the same products, demonstrating that the most probable reaction sites in these molecules do not depend upon whether the chemicai or physicai type of energy is transferred to the molecules. In all the barbituric acid derivatives studied the reaction takes place at the 5-substituent of the compound. The reaction observed is either the loss of the substituent or a change in the substituent. The former reaction is observed in the pharmacologically inactive barbituric acid derivatives, the latter in the active ones.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA