Naslov
Diamantane Alcohols and Hydrophobic Cavities: The Perfect Pair Also in Non-Aqueous Solutions?

Autori
Markuš, Iva ; Usenik, Andrea ; Pičuljan, Katarina ; Alešković, Marija ; Šekutor, Marina ; Požar, Josip

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
27th Croatian Meeting of Chemists and Chemical Engineers and 5th Symposium Vladimir Prelog : Book of Abstracts / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna - Veli Lošinj : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2021, 236-236

Skup
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI) ; 5. simpozij Vladimir Prelog

Mjesto i datum
Veli Lošinj, Hrvatska, 05.10.2021. - 08.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
diamondoid alcohols ; cyclodextrins ; host-guest complexes ; solvophobic effect ; NMR titrations

Sažetak
Diamantane derivatives are excellent guests for cucurbiturils in aqueous solutions, forming complexes with stability constants reaching above petamolar values.[1] On the other hand, their complexation with cyclodextrins has been scarcely explored. We therefore studied temperature and solvent effects on the complexation of diamantane alcohols with cucurbit[7]uril, β- and γ- cyclodextrin by means of isothermal titration calorimetry and NMR spectroscopy. The stability constant among all investigated complexes was by far the highest in the case of the diol derivate with cucurbit[7]uril in water. A pronounced temperature dependence of ΔrH° and ΔrS°, resulting in an almost complete enthalpy-entropy compensation, was observed for most studied host- guest systems. The corres-ponding complexation thermodynamics were in line with the classical rationale of the solvophobic effect at lower temperatures, and the non-classical explanation at higher ones.[2, 3] The results of 1H NMR titrations and ROESY experiments were in line with the thermodynamic studies and have revealed an interesting difference in complex formation kinetics between cucurbit[7]uril and β- cyclodextrin.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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