Naslov
Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
(Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic)

Autori
COVIDSurg Collaborative

Kolaboracija
COVIDSurg Collaborative

Izvornik
Colorectal disease (1462-8910) 23 (2021), 3; 732-749

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cancer ; colon cancer ; COVID-19 ; pandemic ; rectal cancer ; SARS-CoV-2 ; surgery ; surgical oncology

Sažetak
Aim: This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic. Method: This was an international cohort study of patients undergoing elective resection of colon or rectal cancer without preoperative suspicion of SARS-CoV-2. Centres entered data from their first recorded case of COVID-19 until 19 April 2020. The primary outcome was 30-day mortality. Secondary outcomes included anastomotic leak, postoperative SARS-CoV-2 and a comparison with prepandemic European Society of Coloproctology cohort data. Results: From 2073 patients in 40 countries, 1.3% (27/2073) had a defunctioning stoma and 3.0% (63/2073) had an end stoma instead of an anastomosis only. Thirty-day mortality was 1.8% (38/2073), the incidence of postoperative SARS- CoV-2 was 3.8% (78/2073) and the anastomotic leak rate was 4.9% (86/1738). Mortality was lowest in patients without a leak or SARS-CoV-2 (14/1601, 0.9%) and highest in patients with both a leak and SARS-CoV-2 (5/13, 38.5%). Mortality was independently associated with anastomotic leak (adjusted odds ratio 6.01, 95% confidence interval 2.58-14.06), postoperative SARS-CoV-2 (16.90, 7.86-36.38), male sex (2.46, 1.01-5.93), age >70 years (2.87, 1.32-6.20) and advanced cancer stage (3.43, 1.16-10.21). Compared with prepandemic data, there were fewer anastomotic leaks (4.9% versus 7.7%) and an overall shorter length of stay (6 versus 7 days) but higher mortality (1.7% versus 1.1%). Conclusion: Surgeons need to further mitigate against both SARS-CoV-2 and anastomotic leak when offering surgery during current and future COVID- 19 waves based on patient, operative and organizational risks.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

Napomena
Autori na kolaboraciji navedeni na kraju rada (Appendix A: Collaborators)
Writing group:
Bhangu, Aneel; Li, Elizabeth; Glasbey, James C.; Nepogodiev, Dmitri; Simoes, Joana F. F.; Omar, Omar M.; Venn, Mary L.; Evans, Jonathan P.; Futaba, Kaori; Knowles, Charles H.; Minaya-Bravo, Ana; Mohan, Helen; Chand,
Manish; Pockney, Peter; Di Saverio, Salomone; Smart, Neil; Vallance, Abigail; Vimalachandran, Dale; Wilkin, Richard

POVEZANOST RADA