Naslov
Učinkovitost vaskularne ultrazvočne diagnostike za periferno arterijsko bolezen pri pacientih OKUŽENIH S HIV
(Effectiveness of vascular ultrasound diagnostics for peripheral arterial disease in HIV-infected patients)

Autori
Katrin, Nedeljko

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, magistarski rad

Fakultet
Fakulteta za zdravstvene vede

Mjesto
Maribor, Slovenija

Datum
21.10

Godina
2020

Stranica
55

Mentor
Povalej Brižan, Petra ; Višković, Klaudija

Ključne riječi
vascular ultrasound ; peripheral arterial disease ; chronic kidney disease ; HIV infection ; statistical analysis

Sažetak
Peripheral artery disease (PAD) contributes to increased mortality of cardiovascular disease (CVD), especially in HIV-infected patients with chronic kidney disease (CKD). To prevent cardiovascular events in individuals with increased risk, it is important to diagnose PAD in its early stage, as it frequently remains asymptomatic. The aim of this study was to evaluate and categorize PAD by vascular ultrasound and to compare its presence in HIV-infected patients with CKD and HIV-infected patients with normal kidney function. Doppler ultrasound is a precise imaging method for medial and intimal calcification detection, as well as for hemodynamic evaluation of peripheral arteries. It can confirm and localize PAD by visualisation of the vessel wall. There is no risk of ionizing radiation, potential complications regarding contrasts, pain, or high expenses, in comparison to other radiological diagnostic methods. Statistical software IBM SPSS v26 was used for analysis of collected data. PAD, increased carotid intima-media thickness (IMT), mild to moderate medial arterial calcification (MAC) and diffuse MAC were significantly more prevalent in HIV- positive patients with CKD, compared to those without CKD (p=0.009, p=0.045, p=0.007 and p=0.006, respectively), while aortic and femoral intimal calcification between two groups did not significantly differ (p=0.258). HIV-infected individuals with advanced stages of CKD, were significantly more prone to MAC development (p=0.004), compared to patients with lower stages of CKD, while increased carotid IMT, carotid calcification and aortic and femoral intimal calcification did not significantly differ between lower and advanced stages of CKD (p=0.085, p=0.100 and p=0.396, respectively). Older age showed as significant risk factor for PAD, MAC, increased IMT, and aortic and femoral intimal calcification. CKD was additional predictor of PAD and MAC, while CKD and smoking were both identified as significant risk factors for increased IMT. Findings of this study will provide additional information on currently not sufficiently explored problem.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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