Naslov
Chemical profile and enzyme inhibition potential of water extracts from Centaurea plants

Autori
Politeo, Olivera ; Kardum, Kristina ; Ruščić, Mirko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
27th Croatian Meeting of Chemists and Chemical Engineers with International Participation. Book of Abstracts. / - , 2021, 160-160

Skup
27th Croatian Meeting of Chemists and Chemical Engineers with International Participation.

Mjesto i datum
Veli Lošinj, Hrvatska, 05.10.2021. - 08.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Recenziran

Ključne riječi
Asteraceae, Centaurea, chemical profile, AChE, BuChE, a-glucosidase

Sažetak
Inhibition of important enzymes is one of the fundamental therapies for treating diseases such as Alzheimer's dementia and Diabetes mellitus. Genus Centaurea is one of the most important genuses of the Asteraceae family, with a large number of species. In Croatia there are around 80 species of this genus, of which 27 are endemic.In this study, the chemical profile and enzyme inhibition potential of the water extracts of five plants of the genus Centaurea was determined. The chemical profile of the extracts was determined by quantitative determination of the total phenol content and the total flavonoid content. Enzyme inhibition potential of the extracts were investigated in terms of the inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase BuChE) by Ellman method as well as a-glucosidase enzymes by method described from Brueggeman and Hollingsworth.The results showed that all Centaurea water extracts contain a relatively small content of phenolic and flavonoid compounds. C. scabiosa and C. rhenana extracts show low inhibition of AChE, C. triumfetti and C. ragusina show very low inhibition of AChE, whereas C. alba does not inhibit AChE. C. alba, C. rhenana and C. scabiosa extracts poorly inhibiting BuChE, while C. triumfetti and C. ragusina do not inhibit this enzyme. C. scabiosa extract show moderate inhibition on a-glucosidase. C. rhenana extract show low inhibition on a-glucosidase enzyme, while the other extracts do not inhibit this enzyme.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA