Naslov
Specific cognitive deficits in preterm children at preschool age and their relation to white matter changes after perinatal lesion.

Autori
Kostović Srzentić, Mirna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Special Issue Developmental Medicine & Child Neurology, 57, s4, 16. Abstracts of the European Academy of Childhood Disability 27th Annual Meeting, 27–30 May 2015, Copenhagen, Denmark. / - , 2015, 16-16

Skup
European Academy of Childhood Disability 27th Annual Meeting

Mjesto i datum
Kopenhagen, Danska, 27.05.2015. - 30.05.2015

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
specific cognitive deficit, preterm children, white matter lesion

Sažetak
The aim was to examine whether preterm infants with perinatal lesion, beside general cognitive delay, have specific cognitive deficits in preschool age, as well as to analyze relationship between structural MRI brain changes and cognitive functions. Methods: 21 preterms, admitted to neonatal intensive care unit, underwent 2T MRI at term equivalent age (36 to 44 weeks of gestation). Comprehensive cognitive assessment and follow-up 3T MRI executed at the age 3 to 5 years. Wechsler Preschool and Primary Scale of Intelligence WPPSI-III and Developmental Neuropsychological Assessment NEPSY-II (attention, executive functioning, language, memory, learning, sensorimotor and visuospatial processing) were applied. Results: Although mean IQ was in the low average level, one fourth of the sample had significant intellectual delay. Specific cognitive deficits, even in children with normal IQ, were found (narrative memory, executive functions, language, visuomotor and visuospatial processing). Ventricular enlargement and white matter changes (WM) on neonatal MRI in frontal, parietal and occipital lobe correlated to general and specific cognitive functions in preschool age. Follow up MRI in preschool age (time close to the cognitive assessment) showed that corpus callosum area, ventricular enlargement and WM reduction (frontal, parietal, occipital) also correlate with many cognitive functions. Conclusion: Beside general cognitive delay, specific cognitive deficits in children with perinatal brain lesion can be estimated in preschool age, fact especially important in terms of early intervention and neuropsychological assessment. Neonatal MRI changes relate to MRI findings at preschool age, and changes in both measurement periods correlate with cognitive functions in preschool children.

Izvorni jezik
Engleski

Znanstvena područja
Kognitivna znanost (prirodne, tehničke, biomedicina i zdravstvo, društvene i humanističke znanosti)

POVEZANOST RADA