Naslov
Inbreeding and risk of late-onset complex disease

Autori
Rudan, Igor ; Rudan, Diana ; Campbell, Harry ; Carothers, Andrew ; Wright, Alan ; Smolej-Narancic, Nina ; Janicijevic, Branka ; Jin, Li ; Chakraborty, Ranajit ; Deka, Ranjan ; Rudan, Pavao

Izvornik
Journal of Medical Genetics (0022-2593) 40 (2003), 12; 925-932

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
inbreeding; complex disease; genetic isolate

Sažetak
We have proposed that the genetic basis of common, late-onset diseases includes a major class of deletorious recessive alleles, on the basis of population genetic arguments. Inbreeding is therefore predicted to increase the incidence of such diseases. We have investigated this in a genetic isolate population showing a wide range of inbreeding. Inbreeding was found to be a significant (positive) predictor for coronary heart disease, stroke, cancer, uni/bipolar depression, asthma, gout and peptic ulcer, but not for type 2 diabetes. The results indicated that 23-48% of incidence of these disorders (other than type 2 diabetes) in this population could be attributed to inbreeding.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita, Etnologija i antropologija

POVEZANOST RADA