Naslov
Three-step method for the analysis of protein motifs

Autori
Štambuk, Nikola

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts of CECM-2 / Vančik, Hrvoj - Zagreb : Faculty of Science and Mathematics, University of Zagreb & Ruđer Bošković Institute, 2003

Skup
The 2nd Central European Chemical Meeting (CECM-2)

Mjesto i datum
Varaždin, Hrvatska, 19.06.2003. - 21.06.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
amino acid; peptide; DNA; ligand; receptor; antisense box

Sažetak
Peptide motifs of up to fifteen amino acids and their corresponding antisense motifs are thought to be involved in the function of more than forty different peptide-receptor systems. We present three-step strategy of identifying repetitive and possibly bioactive amino acid motifs in proteins. Repetitive peptide boxes are first extracted from the protein. In the second step an algorithm is used to detect the complementary or antisense boxes. When the motifs corresponding to both DNA strands are identified the third step is performed by running them through the database. Homologies to ligands and/or receptors are investigated considering molecular mimicry and functional relationships. Presented method represents one of the possible strategies of investigating new bioactive motifs within proteins.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA