Naslov
Serum metabolomic changes in canine hypothyroidism

Autori
Muñoz Prieto, Alberto ; González Aróstegui, Luis Guillermo ; Rubic, Ivana ; Cerón Madrigal, José Joaquín ; Tvarijonaviciute, Asta ; Horvatić, Anita ; Mrljak, Vladimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Southern European Veterinary Conference-SEVC 2021 ONLINE / - , 2021, Endocrinology-/

Skup
Southern European Veterinary Conference-SEVC 2021 ONLINE

Mjesto i datum
Online;, 19.10.2021. - 22.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Canine hypothyroidism, serum, metabolomics

Sažetak
Canine hypothyroidism is one of the most often diagnosed endocrine disease in dogs characterized by a deficiency of the active thyroid hormones that have a negative impact on dog’s quality of life. The study of metabolic implications related to thyroid hormones can lead to the development of new biomarkers with clinical utility. In this study, we have analyzed 20 serum samples of dogs with hypothyroidism and compared them with 20 healthy dogs using non-target metabolomic techniques. With this approach, two new metabolites that change in serum of dogs with hypothyroidism have been detected. These metabolites are D-gluconic and L-isoleucine, both closely related to the development of complications and could be promising biomarkers of this disease.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Veterinarska medicina

POVEZANOST RADA