Naslov
PARAMETERS OF GLUCOSE METABOLISM IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA

Autori
Zdrilić, Elena

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, diplomski rad, diplomski

Fakultet
Medicinski fakultet

Mjesto
Split

Datum
20.07

Godina
2017

Stranica
44

Mentor
Božić, Joško

Ključne riječi
Sleep Apnea Obstructive, Diabetes Mellitus, Glucose Tolerance Test, Body Mass Index

Sažetak
Objectives: Obstructive sleep apnea (OSA) by its main characteristic of recurrent intermittent hypoxemia is associated with glucose metabolism alterations and insulin resistance, with increased risk for development of diabetes. The aim of the study was to compare parameters of glucose metabolism in non-diabetic OSA patients with respective controls. Materials and methods: A total of 25 male newly diagnosed OSA patients and 25 matched control subjects underwent an oral glucose tolerance test (OGTT) and blood sampling for determination of parameters of glucose metabolism. Insulin resistance was assessed by the homeostatic model assessment index of insulin resistance (HOMA-IR). Results: Fasting plasma glucose level (5.2±0.5 vs. 5.0±0.4 mmol/L ; P=0.023) and fasting plasma insulin level (106.2±72.6 vs. 61.4±30.0 pmol/L ; P=0.006) were significantly higher in OSA group in comparison with control group. There were no significant differences between groups in the postprandial plasma glucose and insulin levels. HOMA-IR was significantly higher in the OSA group in comparison to control group (3.7±2.9 vs. 2.0±1.6 ; P=0.006). In OSA group more patients had impaired fasting glucose (28% vs. 4% ; P=0.020) and insulin resistance (52% vs. 8% ; P=0.007) in comparison with the control group. There was no statistically significant difference in the prevalence of impaired glucose tolerance between groups. Conclusion: In conclusion, this study confirmed the evidence of glucose metabolism disorders in patients with OSA.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA