Naslov
Adamantane-containing desmuramyl peptides: synthesis and structural insight into NOD2 binding

Autori
Paurević, Marija ; Maršavelski, Aleksandra ; Korica, Milenko ; Ribić, Rosana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
27th Croatian Meeting of Chemists and Chemical Engineers and 5th Symposium Vladimir Prelog : Book of Abstracts / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna - Zagreb : Hrvatsko kemijsko društvo, 2021, 216-216

Skup
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI)

Mjesto i datum
Veli Lošinj, Hrvatska, 05.10.2021. - 08.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
desmuramyl peptides, NOD2 receptor, immunostimulation

Sažetak
Muramyl dipeptide (MDP, N-acetylmuramyl-L-alanyl- D-isoglutamine) is a conserved fragment of a bacterial cell walls and the smallest peptidoglycan fragment competent to trigger the immune response. MDP binds to NOD2 (nucleotide binding and oligomerization domain-containing protein 2) with affinity in the nanomolar range. Activation of NOD2 by MDP stimulates downstream signaling pathways and promote immune responses. Minor MDP structure modifications affect molecular recognition by NOD2, and thereby influence the modulation of the immune response. Here we present the synthesis of MDP analogs, desmuramyl peptides (DMPs) with incorporated lipophilic adamantly groups at the N-terminus of the dipeptide pharmacophore. The adamantly group was introduced in two ways, via 2-aminoadamantan- 2-carboxylic acid and via (R)-adamantylglycine. Molecular docking simulations of NOD2 receptor and prepared adamantly DMPs were also performed in order to investigate interactions established between DMPs and receptor protein.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA