Pregled bibliografske jedinice broj: 1154958
Plasma Matrix Gla protein and biochemical parameters in patients with Crohn´s disesase
Plasma Matrix Gla protein and biochemical parameters in patients with Crohn´s disesase, 2019., diplomski rad, diplomski, Medicinski fakultet, Split
CROSBI ID: 1154958 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Plasma Matrix Gla protein and biochemical parameters
in patients with Crohn´s disesase
Autori
Tufteland, Martin
Vrsta, podvrsta i kategorija rada
Ocjenski radovi, diplomski rad, diplomski
Fakultet
Medicinski fakultet
Mjesto
Split
Datum
05.07
Godina
2019
Stranica
52
Mentor
Božić, Joško
Ključne riječi
Chron Disease, Matrix Gla Protein
Sažetak
Objectives: The aim of this study was to investigate plasma Matrix Gla protein (MGP) levels in patients with Crohn’s disease in comparison to control group, while additional goal was to investigate association of plasma MGP levels with disease activity and other biochemical parameters. Materials and methods: A total of 35 patients with Crohn’s disease and 35 sex, age and BMI matched control subjects underwent anthropometric assessment which were measured by calibrated stadiometer with integrated weight scale. Venous blood samples were taken and plasma MGP levels were analyzed by Chemiluminescence immunoassay (CLIA) method using IDS-iSYS InaKtif MGP (Immunodiagnostic Systems, Frankfurt, Germany). Other biochemical parameters were determined by standard laboratory procedures. Results: The plasma MGP levels were significantly higher in the Crohn’s disease patients in comparison to control group (641.1±141.6 vs. 532.6±98.8 pmol/L, P<0.001). Significant positive correlation was found between plasma MGP concentrations and waist circumference and hsCRP (P=0.028 and 0.024, respectively). Furthermore, MGP levels positively correlated with liver function tests. Additionally, significant negative correlation was found between MGP levels and HDL level (r=-0.242, P=0.043). There were no significant correlations between MGP levels and disease duration or fecal calprotectin level. Conclusion: In conclusion, this study confirmed that plasma MGP levels are significantly higher in patients with Crohn’s disease in comparison to control group. Furthermore, plasma MGP levels can be related with disease activity in patients with Crohn’s disease. Further studies are needed to clarify this connection.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
