Naslov
VITAMIN D STATUS IN OBSTRUCTIVE SLEEP APNEA PATIENTS

Autori
Markoski, Blagoja

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, diplomski rad, diplomski

Fakultet
Medicinski fakultet

Mjesto
Split

Datum
26.07

Godina
2019

Stranica
47

Mentor
Božić, Joško

Ključne riječi
Sleep Apnea Obstructive, Vitamin D

Sažetak
Objectives: Obstructive sleep apnea is pathological condition characterized by recurrent episodes of upper airway collapse during sleep and is associated with multiple metabolic conditions including metabolic syndrome and osteoporosis. The aim of the presented study was to compare 25- dihydroxy vitamin D concentrations and other laboratory parameters between OSA patients and healthy control group. Patients and methods: The study included 30 male patients that were diagnosed with OSA and a control group with 30 gender and BMI matched healthy volunteers. All study subjects underwent physical examination and anthropometric measuring. In detailed interview, information regarding physical activity was taken. Polysomnographic recording (PSG) was used on all study group participants. Automated Chemiluminescence Sandwich Immunoassay (CLIA) method was used to assess 25-dihydroxy vitamin D (Immunodiagnostic Systems, Frankfurt, Germany) levels. Intact parathyroid hormone (iPTH) was analyzed with the electrochemiluminescence immunoassay (ECLIA) method on Roche Cobas e601 (Roche Diagnostics, Mannheim, Germany), while calcium and phosphorus concentrations were determined using standard laboratory procedures. Results: There was no difference in serum concentrations of 25-dihydroxy vitamin D in OSA patients and healthy controls, however aaverage 25-dihydroxy vitamin D levels were low in both groups (49.3 ± 15.8 nmol/L vs. 48.2 ± 17.6 nmol/L, P=0.744). There was a significant negative correlation between 25-dihydroxy vitamin D concentrations and BMI (r=-0.304, P=0.018) and waist circumference (r=-0.359, P=0.004). The correlation between AHI and 25-dihydroxy vitamin D levels was not observed (r=0.024, P=0.900). There was no difference in iPTH, calcium or phosphorus levels between OSA patients and controls. Conclusion: There was no difference in serum concentrations of 25-dihydroxy vitamin D in OSA patients and healthy controls, however serum concentrations of 25-dihydroxy vitamin D were low in both groups. Further studies with a larger number of OSA patients are needed to investigate the relationship between OSA and 25-dihydroxy vitamin D levels.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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