Naslov
ANALYSIS OF GENDER AND RACE REPORTING IN RANDOMIZED CONTROLLED TRIALS FOR HEART FAILURE

Autori
Sandhu, Kamaljeet Kaur

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, diplomski rad, diplomski

Fakultet
Medicinski fakultet

Mjesto
Split

Datum
16.07

Godina
2020

Stranica
59

Mentor
Božić, Joško

Ključne riječi
Heart Failure, Sex, Continental Population Groups, Randomized Controlled Trials as Topic

Sažetak
Aim: The aim of this study is to determine the reporting of data on gender and ethnicity in RCTs of interventions for heart failure treatment in the major journals from the field of cardiology from 2017 to 2019. Methods: We analysed 344 RCTs published between January 2017 to December 2019 in top five cardiology journals. Full- length papers on heart failure were analysed for reporting on sex/gender and race/ethnicity considerations. We extracted the data for: journal name, year of publication, study name, sex or race detailed terminology explained, sex or race mentioning in the title, abstract or introduction, number of study participants, number of male and female subjects, list of different ethnic backgrounds, sex and race specific analyses planned in the methods and results, differences in the sex and race specific results, sex and race specific results mentioned in the discussion section and centre of the study. Results: Majority of the RCTs were published in the year 2018 (151 ; 43.9%), followed by 2017 (115 ; 33.4%) and 2019 (78 ; 22.7%). The highest number of RCTs were published in the Journal of the American College of Cardiology (121 ; 35.2%) and Circulation (118 ; 34.3%), whereas lowest numbers were published in the European Heart Journal (10 ; 2.9%). Overall, 63 (18.3%) of published RCTs reported sex/gender in the abstract section, and race/ethnicity was mentioned only in 16 (4.65%). Sex/gender differences from previous studies were mentioned in the Introduction section in 3.5% of the studies, while race differences in only 2.91%. Most of the papers in this study (N=305 ; 88.6%) mentioned sex/gender in any of the sections, while race/ethnicity was mentioned in a total of 212 papers (61.6%). In the methods section, 35 (10.2%) papers described plans to examine results separately by sex/gender, and only 17 (4.9%) overall planned to examine differences in race/ethnicity in their research. In a total of 180 (52.3%) papers, at least one analysis in results section was included based on gender, while race specific results were reported in 67 (19.4%) papers. White population was included in highest number of papers (N=71), and studies with white population included significantly larger number of participants (1086 (103.5-3633)) in comparison with others (P<0.001). Conclusion: With sex/gender and race/ethnicity specific analyses neglected in majority of the included studies, researchers should invest more efforts to plan, conduct and report sex/gender and race/ethnicity outcomes in future RCTs.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA