Naslov
ADROPIN IN PATIENTS WITH HEART FAILURE

Autori
Scimeca, Giovanni

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, diplomski rad, diplomski

Mjesto
Split

Datum
17.07

Godina
2020

Stranica
51

Mentor
Božić, Joško

Ključne riječi
Heart Failure

Sažetak
Objectives: The aim of this study is to determine serum adropin levels in patients with heart failure in comparison with healthy controls. Patients and methods: This study enrolled a total of 30 heart failure patients and 30 healthy control subjects. The heart failure patients were evaluated in the first 24 hours of hospital admission. Evaluation included physical examination, medical history, venous blood sampling, blood pressure measurement, and transthoracic echocardiography (TTE). American Society of Echocardiography (ASE) guidelines were used for TTE examination. Laboratory analyses of collected venous blood samples was performed at Department of Medical Laboratory Diagnostics by experienced biochemist that was blinded to subject group assignment. Serum adropin levels were determined with dual enzyme-linked immunosorbent assay (ELISA) (Phoenix Pharmaceuticals, Burlingame, USA). Results: Patients with heart failure had significantly higher serum levels of adropin compared to the control group (7.1 ± 0.56 vs 4.23 ± 0.31 ng/mL, P<0.001). We found a positive correlation between serum adropin and NYHA score (r = 0.389, P=0.002), NT-proBNP (r = 0.393, P=0.001) and BMI (r = 0.256, P=0.035). A negative correlation was found between serum adropin and LVEF (r = -0.325, P=0.011) and CRP (r = -0.259, P=0.045). Conclusions: Serum adropin is significantly increased in people with heart failure compared to the control group which implies possible involvement of adropin in heart failure pathophysiology. However, future larger multicentric studies are needed to address these findings.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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