Naslov
A Guide to Adhesion GPCR research

Autori
Ines Liebscher, Orkun Cevheroglu, Cheng-Chih Hsiao, André F. Maia, Hannes Schihada, Nicole Scholz, Mark Soave, Katja Spiess, Katarina Trajkovic, Mickey Kosloff, Simone Prömel

Izvornik
The FEBS journal (1742-464X) 1 (2021), 1; 1-42

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Adhesion GPCRs ; clinical application ; physiology ; signaling ; structure-function

Sažetak
Adhesion G protein-coupled receptors (aGPCRs) are a class of structurally and functionally highly intriguing cell surface receptors with essential functions in health and disease. Thus, they display a vastly unexploited pharmacological potential. Our current understanding of the physiological functions and signaling mechanisms of aGPCRs form the basis for elucidating further molecular aspects. Combining these with novel tools and methodologies from different fields tailored for studying these unusual receptors yields a powerful potential for pushing aGPCR research from singular approaches towards building up an in-depth knowledge that will facilitate its translation to applied science. In this review, we summarize the state of the art knowledge on aGPCRs in respect to structure-function relations, physiology, and clinical aspects, as well as the latest advances in the field. We highlight the upcoming most pressing topics in aGPCR research and identify strategies to tackle them. Further, we discuss approaches how to promote, stimulate and translate research on aGPCRs "from bench to bedside" in the future.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA