Pregled bibliografske jedinice broj: 115489
A polygenic basis for late-onset disease
A polygenic basis for late-onset disease // Trends in Genetics, 19 (2003), 2; 97-106 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 115489 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
A polygenic basis for late-onset disease
Autori
Wright, Alan ; Charlesworth, Brian ; Rudan, Igor ; Carothers, Andrew ; Campbell, Harry
Izvornik
Trends in Genetics (0168-9525) 19
(2003), 2;
97-106
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
polygenic traits; genetics; humans; complex diseases
Sažetak
The biological basis of late-onset disease has been shaped by genetic factors subject to varying degrees of evolutionary constraint. Late-onset traits are not only more sensitive to environmental variation, owing to the breakdown of homeostatic mechanisms, but they also show higher levels of genetic variation than traits directly influencing reproductive fitness. The origin and nature of this variation suggests that current strategies are poorly suited to identifying genes involved in many complex diseases.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- Excerpta Medica
- Index Medicus
