Naslov
High-resolution mass spectrometry characterization of cinnarizine – β-cyclodextrin inclusion complexes

Autori
Klarić, David ; Galić, Nives

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
27th Croatian Meeting of Chemists and Chemical Engineers and 5th Symposium Vladimir Prelog : Book of Abstracts / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna - Zagreb : Hrvatsko kemijsko društvo, 2021, 101-101

Skup
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI)

Mjesto i datum
Veli Lošinj, Hrvatska, 05.10.2021. - 08.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
cinnarizine ; cyclodextrin ; inclusion complexes ; mass spectrometry

Sažetak
Cinnarizine (CIN) is a piperazine derivative with antihistaminic and calcium channel blocking activity which is widely used for the treatment of vertigo and prevention of motion sickness. Due to its poor aqueous solubility, CIN is classified as a Class 2 drug substance according to The Biopharmaceutical Classification System [1]. It is known that cyclodextrins (CDs) can interact with poorly soluble drugs by forming inclusion and non- inclusion complexes and thus enhance drug aqueous solubility and bioavailability [2]. The aim of our study was to characterize complexes of CIN with natural β-CD and its hydroxypropyl (HPβCD) and randomly methylated (RMβCD) derivatives by electrospray ionization mass spectrometry (MS) since this technique can offer direct determination of CD inclusion complexes formation and their stoichiometry [3]. High- resolution quadrupole time-of-flight (Q-TOF) mass spectrometer system was used for obtaining MS spectra. In order to determine binding strength of the complexes, MS/MS experiments were performed. Corresponding collision energy breakdown curves were constructed and fragmentation schemes were suggested as well. REFERENCES [1] S. Raghuvanshi, K. Pathak, J. Drug Delivery 2014, 2014, 479246. [2] S. V. Kurkov, T. Loftsson, Int. J. Pharm. 2013, 453, 167–180. [3] M. Silion et al. in A. G. Woods, C. C. Darie (eds), Advancements of Mass Spectrometry in Biomedical Research, Adv. Exp. Med. Biol. 2019, 1140, 685–701.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA