Naslov
REGULATION OF MITOPHAGY RECEPTORS BY PHOSPHORYLATION

Autori
Marinković, Mija ; Rogov, Vladimir ; Suzuki, Hironori ; Lang, Verena ; Kato, Ryuichi ; Kawasaki, Masato ; Buljubašić Maja ; Hamacher- Brady, Anne ; Dötsch, Volker ; Wakatsuki, Soichi ; Brady, Nathan ; Đikić, Ivan , Novak, Ivana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Skup
EMBO Conference Series: Autophagy signalling and progression in health and disease

Mjesto i datum
Chia, Italija, 09.09.2015. - 12.09.2015

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
mitophagy, autophagy, NIX

Sažetak
Discoveries of autophagic receptors that recognize specific cellular cargo have opened a new chapter in autophagy field. Selective removal of damaged organelles or protein aggregates is essential for the proper cellular homeostasis and survival. We have recently identified and characterized Nix/Bnip3 and Bnip3 mitochondrial proteins as mitophagy receptors that, in LIR- dependent manner, interact with Atg/LC3/GABARAP proteins and recruit autophagic machinery to damaged mitochondria. Moreover, we have shown that Nix/Bnip3L mediates mitochondrial clearance during reticulocyte differentiation. At the moment, we are investigating the phosphorylation status of Nix/Bnip3L and Bnip3 in regulation of mitophagy. Our current results show that phosphorylation of mitophagy receptors Nix/Bnip3L and Bnip3 are essential for the initiation of mitoichondrial sequestration by autophagic machinery and are involved in fine-tuning of mitophagy.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA