Naslov
Synthesis and Characterization of Oxazoline Amino Acid Bioconjugates

Autori
Bakija, Marija ; Perić, Berislav ; Kirin, Srećko, I.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
27th Croatian Meeting of Chemists and Chemical Engineers and 5th Symposium Vladimir Prelog : Book of Abstracts / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna - Zagreb : Hrvatsko kemijsko društvo, 2021, 165-165

Skup
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI)

Mjesto i datum
Veli Lošinj, Hrvatska, 05.10.2021. - 08.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
oxazoline ; monodenatate ; rhenium

Sažetak
One of the main concerns of drug development is the transfer through the cell membrane, and even further, through the nuclear membrane via protein transduction domains, a class of diverse peptides that can target intracellular proteins [1]. In our previous work it was shown that attaching metal complexes to a protein transduction domain does facilitate the transport to the cell nucleus [2]. In this communication, oxazoline amino acid bioconjugates 1-3 were prepared, containing none, one or two amino acid strands, Figure 1. The bioconjugates were characterized by NMR and IR spectroscopy and MS spectrometry. Initial synthetic studies with several inorganic or organometallic precursors will be reported. The metallated model compounds that show the best results will be chosen for further investigation with longer amino acid strands.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA