Naslov
Synthesis, photochemistry and biological activity of new 1,2,3-triazolostilbenes. An experimental and computational study

Autori
Mlakić, Milena ; Odak, Ilijana ; Talić, Stanislava ; Faraho, Ivan ; Bosnar, Martina ; Barić, Danijela ; Škorić, Irena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
27th Croatian Meeting of Chemists and Chemical Engineers and 5th Symposium Vladimir Prelog : Book of Abstracts / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić , Vesna - : Hrvatsko kemijsko društvo, 2021, 135-135

Skup
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI) ; 5. simpozij Vladimir Prelog

Mjesto i datum
Veli Lošinj, Hrvatska, 05.10.2021. - 08.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
electrocyclization photoproducts ; cholinesterase inhibition, inhibition of TNFalpha cytokine production ; computer modeling

Sažetak
Triazoles present an important class of heterocyclic compounds exhibiting a wide range of pharmacological activities [1]. New 1, 2, 3- triazolostilbenes were synthesized and photochemically transformed to electrocyclization products in high yields for the purpose of studying their acetyl- and butyrylcholinesterase inhibition and anti-inflammatory activity [2]. In our previous paper [3], photoreactivity of 1, 2, 3- ditriazolostilbenes were investigated showing unreactivity toward the electrocyclization. In contrast, 1, 2, 3-triazolostilbenes gave electrocyclization photoproducts in high isolated yields providing especially interesting results on cholinesterase inhibition associated with the inhibition of TNFalpha cytokine production. Additionally, the electronic structure of the obtained 1, 2, 3-triazolostilbenes and the thermodynamic stability of the 1, 2, 3- triazolostilbenes - cholinesterases complexes were investigated by computer modeling. REFERENCES [1] O. Silakari, Molecules 2018, 9, 1-29. [2] S. Vakine, H. Soreq, Neuropharmacology 2020, 168, 108020. [3] A. Ratković, M. Mlakić, W. Dehaen, T. Opsomer, D. Barić, I. Škorić, Spectrochim acta A 2021, 261, 120056.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA