Naslov
Do We Follow The Current Guidelines For The Treatment Of Metastatic Hormone-Dependent, Her2 Negative Breast Cancer With Characteristics Of Endocrine Resistance? Retrospective Analysis Of Patients Treated With Cdk 4/6 Inhibitors In Uhc Zagreb
(Do We Follow The Current Guidelines For The Treatment Of Metastatic Hormone-Dependent, Her2 Negative Breast Cancer With CharacteristicsOf Endocrine Resistance? Retrospective Analysis Of Patients Treated With Cdk 4/6 Inhibitors In Uhc Zagreb)

Autori
Glas, Ana Magdalena ; Čular, Katarina ; Dedić Plavetić, Natalija ; Popović, Marina ; Silovski, Tajana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Liječnički vjesnik / Pleština, Stjepko ; Dedić Plavetić, Natalija ; Tomek, Dora - Zagreb, 2020, 86-87

Skup
12. kongres Hrvatskog društva za internističku onkologiju HLZ-a s međunarodnim sudjelovanjem

Mjesto i datum
Zagreb, Hrvatska, 23.11.2020. - 27.11.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
metastatic, breast cancer, endocrine resistance, CDK4/6

Sažetak
Introduction: According to the 5th ESO-ESMO International Guidelines for Advanced Breast Cancer, primary endocrine resistance is defined as recurrence during the first 2 years of adjuvant endocrine therapy (ET) or disease progression within the first 6 months of first-line ET for metastatic breast cancer (mBC). The same guidelines define secondary endocrine resistance as disease progression during or within 12 months of finishing adjuvant ET but after the first 2 years of treatment or progression after 6 or more months of ET for mBC. CDK 4/6 inhibitors in combination with ET are indicated as treatment for hormone sensitive (HR+) HER2 negative (–) mBC. For endocrine resistant population, the optimal endocrine partner of CDK4/6 inhibitor is fulvestrant. The aim of this study was to determine how much we adhere to the guidelines for treatment of the endocrine-resistant population in everyday clinical practice. Methods: We conducted a retrospective observational cross- sectional study by analyzing UHC Zagreb database for the 203 patients with HR+HER– mBC treated with CDK 4/6 inhibitors (palbociklib, ribociclib and abemaciclib). Of these, 83 were endocrine sensitive, 37 primary endocrine resistant, and 83 secondary resistant. Among the endocrine-resistant patients, we singled out 13 patients for whom the criteria of non-compliance with the guidelines was met. Result: Median patients’ age was 62 years (30–84) and the median follow-up was 12 months (1– 32). Of 120 endocrine-resistant, 13 patients progressed during or within 12 months of finishing adjuvant endocrine therapy, and as an endocrine partner of CDK 4/6 inhibitor an aromatase inhibitor was administered instead of the recommended fulvestrant. Conclusion: A retrospective analysis of endocrine resistant cohort revealed that although optimal endocrine partner of CDK4/6 inhibitor in this population is fulvestrant, this fact was overlooked in 10.8% of patients. A larger number of patients and longer follow-up are needed to analyze progression-free survival in the group of patients whose treatment was inconsistent with the guidelines.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA