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Pregled bibliografske jedinice broj: 1147217

Inactivation of the glutathione peroxidase GPx4 by the ferroptosis‐inducing molecule RSL3 requires the adaptor protein 14‐3‐3ε

Vučković, Ana‐Marija; Bosello Travain, Valentina; Bordin, Luciana; Cozza, Giorgio; Miotto, Giovanni; Rossetto, Monica; Toppo, Stefano; Venerando, Rina; Zaccarin, Mattia; Maiorino, Matilde et al.
Inactivation of the glutathione peroxidase GPx4 by the ferroptosis‐inducing molecule RSL3 requires the adaptor protein 14‐3‐3ε // FEBS letters, 594 (2019), 4; 611-624 doi:10.1002/1873-3468.13631 (međunarodna recenzija, članak, znanstveni)

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Naslov
Inactivation of the glutathione peroxidase GPx4 by the ferroptosis‐inducing molecule RSL3 requires the adaptor protein 14‐3‐3ε

Autori
Vučković, Ana‐Marija ; Bosello Travain, Valentina ; Bordin, Luciana ; Cozza, Giorgio ; Miotto, Giovanni ; Rossetto, Monica ; Toppo, Stefano ; Venerando, Rina ; Zaccarin, Mattia ; Maiorino, Matilde ; Ursini, Fulvio ; Roveri, Antonella

Izvornik
FEBS letters (0014-5793) 594 (2019), 4; 611-624

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
14-3-3 proteins ; ferroptosis ; glutathione peroxidase 4 ; protein ; protein interaction ; redox regulation ; RSL3

Sažetak
Ras-selective lethal small molecule 3 (RSL3), a drug candidate prototype forcancer chemotherapy, triggers ferroptosis by inactivating the glutathione per-oxidase glutathione peroxidase 4 (GPx4). Here, we report the purification ofthe protein indispensable for GPx4 inactivation by RSL3. Mass spectrometricanalysis identified 14-3-3 isoforms as candidates, and recombinant human 14- 3-3e confirms the identification. The function of 14-3-3e is redox-regulated.Moreover, overexpression or silencing of the gene coding for 14-3-3e consis-tently controls the inactivation of GPx4 by RSL3. The interaction of GPx4with a redox- regulated adaptor protein operating in cell signaling further con-tributes to frame it within redox-regulated pathways of cell survival and deathand opens new therapeutic perspectives.

Izvorni jezik
Engleski



POVEZANOST RADA

Profili:

Avatar Url Ana-Marija Vučković (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Vučković, Ana‐Marija; Bosello Travain, Valentina; Bordin, Luciana; Cozza, Giorgio; Miotto, Giovanni; Rossetto, Monica; Toppo, Stefano; Venerando, Rina; Zaccarin, Mattia; Maiorino, Matilde et al.
Inactivation of the glutathione peroxidase GPx4 by the ferroptosis‐inducing molecule RSL3 requires the adaptor protein 14‐3‐3ε // FEBS letters, 594 (2019), 4; 611-624 doi:10.1002/1873-3468.13631 (međunarodna recenzija, članak, znanstveni)
Vučković, A., Bosello Travain, V., Bordin, L., Cozza, G., Miotto, G., Rossetto, M., Toppo, S., Venerando, R., Zaccarin, M. & Maiorino, M. (2019) Inactivation of the glutathione peroxidase GPx4 by the ferroptosis‐inducing molecule RSL3 requires the adaptor protein 14‐3‐3ε. FEBS letters, 594 (4), 611-624 doi:10.1002/1873-3468.13631.
@article{article, author = {Vu\v{c}kovi\'{c}, Ana‐Marija and Bosello Travain, Valentina and Bordin, Luciana and Cozza, Giorgio and Miotto, Giovanni and Rossetto, Monica and Toppo, Stefano and Venerando, Rina and Zaccarin, Mattia and Maiorino, Matilde and Ursini, Fulvio and Roveri, Antonella}, year = {2019}, pages = {611-624}, DOI = {10.1002/1873-3468.13631}, keywords = {14-3-3 proteins, ferroptosis, glutathione peroxidase 4, protein, protein interaction, redox regulation, RSL3}, journal = {FEBS letters}, doi = {10.1002/1873-3468.13631}, volume = {594}, number = {4}, issn = {0014-5793}, title = {Inactivation of the glutathione peroxidase GPx4 by the ferroptosis‐inducing molecule RSL3 requires the adaptor protein 14‐3‐3ε}, keyword = {14-3-3 proteins, ferroptosis, glutathione peroxidase 4, protein, protein interaction, redox regulation, RSL3} }
@article{article, author = {Vu\v{c}kovi\'{c}, Ana‐Marija and Bosello Travain, Valentina and Bordin, Luciana and Cozza, Giorgio and Miotto, Giovanni and Rossetto, Monica and Toppo, Stefano and Venerando, Rina and Zaccarin, Mattia and Maiorino, Matilde and Ursini, Fulvio and Roveri, Antonella}, year = {2019}, pages = {611-624}, DOI = {10.1002/1873-3468.13631}, keywords = {14-3-3 proteins, ferroptosis, glutathione peroxidase 4, protein, protein interaction, redox regulation, RSL3}, journal = {FEBS letters}, doi = {10.1002/1873-3468.13631}, volume = {594}, number = {4}, issn = {0014-5793}, title = {Inactivation of the glutathione peroxidase GPx4 by the ferroptosis‐inducing molecule RSL3 requires the adaptor protein 14‐3‐3ε}, keyword = {14-3-3 proteins, ferroptosis, glutathione peroxidase 4, protein, protein interaction, redox regulation, RSL3} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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