Pregled bibliografske jedinice broj: 1146827
Organosilica Nanoparticles for Gemcitabine Monophosphate Delivery in Cancer Cells
Organosilica Nanoparticles for Gemcitabine Monophosphate Delivery in Cancer Cells // ChemNanoMat, 5 (2019), 7; 888-896 doi:10.1002/cnma.201900202 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1146827 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Organosilica Nanoparticles for Gemcitabine
Monophosphate Delivery in Cancer Cells
Autori
Daurat, Morgane ; Rahmani, Saher ; Bouchal, Roza ; Akrout, Alia ; Budimir, Jelena ; Nguyen, Christophe ; Charnay, Clarence ; Guari, Yannick ; Richeter, Sébastien ; Raehm, Laurence ; Bettache, Nadir ; Gary‐Bobo, Magali ; Durand, Jean‐Olivier ; Hesemann, Peter
Izvornik
ChemNanoMat (2199-692X) 5
(2019), 7;
888-896
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
gemcitabine monophosphate ; organosilica nanoparticles ; drug delivery ; cancer ; ionosilica
Sažetak
Organosilica nanoparticles hold great promise for nanomedicine applications. These nanoparticles are synthesized from polytrialkoxysilylated precursors without any silica source. In this work we present two kinds of organosilica nanoparticles with either amine or ammonium walls constituting their structure. Both types of nanoparticles are very efficient for gemcitabine monophosphate delivery, a small hydrophilic anticancer drug whose encapsulation is still a challenge. The nanoparticles are endocytosed by MCF-7 breast cancer cells as monitored by confocal microscopy. They are efficient and lead to 60% cancer cell death.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija, Interdisciplinarne prirodne znanosti, Farmacija
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
